Val Lishman Health Research Foundation Inc » Current Research » Australian NZ Breast Cancer Trials Group

ALTTO: A Clinical Trial for women with breast cancer comparing Herceptin (intravenous therapy) as treatment with both Herceptin and Lapatinib (tablets) together. The trial is researching the scheduling of the treatments and the order in which the therapies are given. It is conducted over 12 months and patients are followed up for 5 years. We are no longer recruiting to this trial.

SOFT: A Clinical Trial for women with breast cancer that studies the effect of suppressing ovarian function in pre-menopausal women. There are 3 arms - Tamoxifen only, Tamoxifen with ovarian suppression and Exemestane with ovarian suppression. Women who are randomized into an arm with ovarian suppression can choose how that is achieved. This trial is conducted over 5 years. We are still recruiting to it to this trial.

CO-SOFT: A sub-study of the SOFT trial which evaluates and compares changes in cognitive function. Women in this study undertake a computer-based cognitive test before they commence treatment and again after 12 months and 5 years. This trial is open for recruitment.

POEMS: A Clinical Trial for young pre-menopausal women with breast cancer which trials a therapy to reduce ovarian failure from chemotherapy. This trial is open for recruitment.

LATER: A Clinical Trial for post-menopausal women who have had breast cancer in the past. This trial is for women who have completed 5 years of therapy and looks at adding Letrozole to the usual therapy with the aim of preventing a new breast cancer forming. We have not yet started recruiting to this trial but should commence in the next few weeks.

PACCT: A new Clinical Trial that should be up and running in a few weeks. A very different trial that integrates a new molecular diagnostic test into decisions regarding treatment which will potentially lead to individualized treatment options. We hope to start recruiting patients in the next few weeks.

2. Pharmaceutical Company Trials

S380: A Clinical Trial comparing different treatment regimens for patients with advanced lung cancer. We are no longer recruiting patients to this trial which is due to finish soon.

3. Australasian Gastro-intestinal Trials Group (AGITG)

Quasar 2: A Clinical Trial for patients with bowel cancer which compares current post-surgery therapy (Xeloda tablets) with a combination of Xeloda and Avastin which is an intravenous chemotherapy. The purpose of the trial is study if the new combination is more effective at stopping the cancer coming back. The trial is conducted over 6 or 12 months. It is open for recruitment.